Biomarker Panel for Chronic Graft-Versus-Host Disease
نویسندگان
چکیده
منابع مشابه
A biomarker panel for acute graft-versus-host disease.
No validated biomarkers exist for acute graft-versus-host disease (GVHD). We screened plasma with antibody microarrays for 120 proteins in a discovery set of 42 patients who underwent transplantation that revealed 8 potential biomarkers for diagnostic of GVHD. We then measured by enzyme-linked immunosorbent assay (ELISA) the levels of these biomarkers in samples from 424 patients who underwent ...
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Whilst many chronic graft versus host disease (cGVHD) biomarkers have been previously reported, few have been verified in an independent cGVHD cohort. We aimed to verify the diagnostic accuracy of previously reported markers of cGVHD in a multi-centre Chronic GVHD Consortium. A total of 42 RNA and 18 protein candidate biomarkers were assessed amongst 59 cGVHD cases and 33 matched non-GVHD contr...
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Mr. F is a 62-year-old Caucasian man who was diagnosed with acute myelogenous leukemia (AML) 15 months prior. Following two cycles of induction chemotherapy, his AML was in remission. Four months ago, after a reduced-intensity conditioning regimen, Mr. F received an allogeneic peripheral blood stem cell transplant from his human leukocyte antigen–identical 56year-old sister. Mr. F received a re...
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255 PRF deficiency occurs not only with allelic variants characterized by mutations in the coding region of the gene. McIlroy et al. reported that the occurrence of a C/T polymorphism at position-398 of the proximal promoter region of the PRF1 gene was associated with decreased quantities of PRF in CTLs in HIV infected patients. A decrease of about 50% of control PRF levels was observed in hete...
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SIR—In previous studies, the presence of arthralgias and transitory arthritis in graft-versus-host disease (GVHD) has been reported, but not chronic arthritis. We will consider a case of non-erosive polyarthritis after a bone marrow transplantation in the context of chronic GVHD. A 32-yr-old male was diagnosed at the age of 27 as having acute myeloblastic leukosis. One year after the diagnosis,...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2016
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2015.65.9615